Management of febrile neutropenia: ESMO clinical recommendations.

نویسندگان

  • F Marti Marti
  • M H Cullen
  • F Roila
چکیده

Despite major advances in prevention and treatment, febrile neutropenia (FN) remains one of the most feared complications of cancer chemotherapy, and is a major cause of morbidity, healthcare resource use, and results in delays and dose reductions in chemotherapy which compromise efficacy. Mortality from FN has diminished steadily but remains significant. Overall mortality rates are 5% in patients with solid tumors (1% in low-risk patients) and as high as 11% in some hematological malignancies. A widely used definition of FN is an axillary temperature >38.5 C lasting >1 h in the context of an absolute neutrophil count (ANC) <0.5 · 10/l. Different centers experience different patterns of principal causative pathogens and these guidelines are intended for use alongside local antimicrobial policies.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Management of febrile neutropaenia: ESMO Clinical Practice Guidelines.

Management of febrile neutropenia: ESMO Clinical Practice Guidelines J. de Naurois, I. Novitzky-Basso, M. J. Gill, F. Marti Marti, M. H. Cullen & F. Roila On behalf of the ESMO Guidelines Working Group* Department of Medical Oncology; Department of Haematology; Department of Clinical Microbiology, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK; Department of Medical Oncolog...

متن کامل

Management of Febrile Neutropenia in Children with Cancer; a Practical Guide to Diagnosis and Treatment

This study aimed to provide an evidence-based guideline for the clinical management of febrile neutropenia in children with cancer. In this narrative review, the most recently published sources of information on febrile neutropenia consisting of textbooks and articles, have been reviewed. We focused on the more recent data about diagnosis, treatment and management in children through the use o...

متن کامل

Factors Associated with Adverse Outcome in Pediatric Febrile Neutropenia: Results from a Tertiary Care Hospital

Background Febrile neutropenia with childhood cancer alters the outcome significantly. To study the clinical and laboratory parameters, which predict the outcome among cancer patients with febrile neutropenia this study was undertaken. Materials and Methods The study included children less than 18 years with febrile neutropenia episodes. Clinical and hematological / laboratory parameters were r...

متن کامل

Comparison of the effects of two different doses of Filgrastim in febrile neutropenia management in childhood malignancy: A randomized clinical trial

Background: Febrile neutropenia (FN) is most often caused due to chemotherapy. Solid or certain lymphoproliferative malignancies can increase the duration of hospitalization and other complications in cancer patients. Filgrastim is used in childhood FN management. This study aimed to compare the effect of two different doses of Filgrastim on hematological and paraclinical factors in hospitalize...

متن کامل

How I diagnose and treat neutropenia.

PURPOSE OF REVIEW Neutropenia absolute neutrophil count (ANC) less than 1.5 × 10(9)/l is a common hematological finding, and severe neutropenia, that is, ANC less than 0.5 × 10(9)/l is a well known risk factor for susceptibility to bacterial infections. This review provides a succinct clinical approach to the diagnosis and treatment of neutropenia with specific recommendations on the treatment ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Annals of oncology : official journal of the European Society for Medical Oncology

دوره 20 Suppl 4  شماره 

صفحات  -

تاریخ انتشار 2009